Appendage Meaning of Appendage In medicine, a body part (such as an arm or leg) that is attached to the main part of the body. Also See: Anti-CD22 immunotoxin CAT-8015 Adrenal gland Abemaciclib Amonafide Warm Up Alveoli Ado-trastuzumab emtansine Antiandrogen Therapy Achlorhydria Alprazolam